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KMID : 0378019610040050051
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New Medical Journal
1961 Volume.4 No. 5 p.51 ~ p.54
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The Histamine Skin Reaction in the Allergic Diseases
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李明秀/Lee, Myung Soo
金順昌/趙炳釵/Kim, Soon Chang/Cho, Byung Chai
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Abstract
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The incidence of hypersensitive reactions increase as new drugs are developed. This is particularly true in this antibiotic era. There are several methods used to detect the presence of a hypersensititive state e.g. Prausnitz- Kustner reaction, Zadssohns eczematous reation, and the specific conjunctival reaction(ETC).
Our experiment was purposed to evaluate the differences of histamine skin reactions among control, non-hypersensitive and hypersensitive groups.
0.1 c.c. of histamine phosphate(0.001 gm) was injected intradermally on the midforearm in three groups, a control group, a non-hypersensitive group, and a hypersensitive group. A planimeter was used to measure the area of reaction 5, 10, 20, 30, 40; 50 and 60 minutes after the injection of the histamine.
Our findings were as follow:
1) The hypersensitive and non-hypersensitive groups showed a significant increase in the area of the reaction over that of the control group.
2) There was no significant sex difference in the degree of skin reaction.
3) The greatest degree of reaction occurred in 30 minutes after the injection.
4) The greatest degree of reaction was seen in the age group from 41 to 50.
5) The average area of reaction in the hpersensitive patients was 5.80 cm2. In the non-hypersensitive patients, it was 4.57 cm2, however there was no statistically important difference in both groups.
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